Cellular targets of interleukin-18 in rheumatoid arthritis
نویسندگان
چکیده
منابع مشابه
Role of interleukin 18 in rheumatoid arthritis.
These include: References http://ard.bmjjournals.com/cgi/content/full/62/suppl_2/ii48#BIBL This article cites 19 articles, 14 of which can be accessed free at: Rapid responses http://ard.bmjjournals.com/cgi/eletter-submit/62/suppl_2/ii48 You can respond to this article at: service Email alerting top right corner of the article Receive free email alerts when new articles cite this article sign u...
متن کاملSerum interleukin 18 and interleukin 18 binding protein in rheumatoid arthritis.
OBJECTIVE To measure serum interleukin 18 (IL18) and IL18 binding protein (IL18BP) levels in patients with inflammatory arthropathies, and to identify associations with disease status and the response to treatment. METHODS Serum samples were obtained before and after methotrexate treatment from patients with rheumatoid arthritis (RA) and psoriatic arthritis (PsA) attending an early arthritis ...
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Interleukin 18 (IL-18), a member of the IL-1 superfamily of cytokines has been demonstrated to be an important mediator of both innate and adaptive immune responses. Several reports have implicated its role in the pathogenesis of rheumatoid arthritis (RA). Although biologic therapy is firmly established in the treatment of a number of inflammatory diseases including RA, partial and non-responde...
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The aim of this study was to investigate the association of interleukin-18 (IL-18) promoter single nucleotide polymorphisms (SNPs) at - 607 and - 137 regions with risk for rheumatoid arthritis (RA) and their association with activity and severity of the disease. The study included 80 RA patients and 80 age and sex matched healthy subjects. Forty RA patients and 40 control subjects were randomly...
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RA is a chronic, debilitating disease in which articular inflammation and joint destruction are accompanied by systemic manifestations including anaemia, fatigue and osteoporosis. IL-6 is expressed abundantly in the SF of RA patients and is thought to mediate many of the local and systemic effects of this disease. Unlike a number of other cytokines, IL-6 can activate cells through both membrane...
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ژورنال
عنوان ژورنال: Annals of the Rheumatic Diseases
سال: 2007
ISSN: 0003-4967
DOI: 10.1136/ard.2006.067793